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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKAR1A
All Species:
42.12
Human Site:
S258
Identified Species:
66.19
UniProt:
P10644
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10644
NP_002725.1
381
42982
S258
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Chimpanzee
Pan troglodytes
XP_511647
260
29299
Q166
I
A
G
E
T
V
I
Q
Q
G
D
E
G
D
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537577
381
43019
S258
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBC7
381
43167
S258
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Rat
Rattus norvegicus
P09456
381
43076
S258
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509586
626
69567
S503
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Chicken
Gallus gallus
Q5ZM91
382
43332
S259
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Frog
Xenopus laevis
NP_001085084
381
43157
S258
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Zebra Danio
Brachydanio rerio
NP_001017732
379
43009
S256
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16905
376
42221
S253
S
R
V
S
I
L
E
S
L
D
K
W
E
R
L
Honey Bee
Apis mellifera
XP_396167
372
41646
A266
A
D
A
L
E
P
V
A
F
D
D
G
E
T
I
Nematode Worm
Caenorhab. elegans
P30625
366
41449
A255
E
R
A
N
V
A
D
A
L
E
R
C
D
F
E
Sea Urchin
Strong. purpuratus
Q26619
369
41770
G263
V
T
R
T
Y
E
D
G
D
C
I
I
A
Q
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07278
416
47201
S305
K
S
M
P
V
L
K
S
L
T
T
Y
D
R
A
Red Bread Mold
Neurospora crassa
Q01386
385
42138
T264
E
E
V
P
I
L
K
T
L
T
P
Y
E
R
S
Conservation
Percent
Protein Identity:
100
68.2
N.A.
97.9
N.A.
96.8
97.3
N.A.
58.7
92.4
92.6
91.5
N.A.
71.3
74
57.7
39.3
Protein Similarity:
100
68.2
N.A.
98.1
N.A.
97.3
98.4
N.A.
60
96
95.8
95.8
N.A.
81.6
85.3
73.4
56.9
P-Site Identity:
100
0
N.A.
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
13.3
6.6
0
P-Site Similarity:
100
6.6
N.A.
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
100
33.3
60
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.2
34
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.7
52.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
40
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
14
0
0
7
0
14
0
0
0
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% C
% Asp:
0
7
0
0
0
0
14
0
7
67
14
0
14
7
0
% D
% Glu:
14
7
0
7
7
7
60
0
0
7
0
7
74
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% F
% Gly:
0
0
7
0
0
0
0
7
0
7
0
7
7
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
0
67
0
7
0
0
0
7
7
0
0
7
% I
% Lys:
7
54
0
0
0
0
14
0
0
0
60
0
0
0
0
% K
% Leu:
0
0
0
7
0
74
0
0
80
0
0
0
0
0
60
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% N
% Pro:
0
0
0
14
0
7
0
0
0
0
7
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
7
7
0
0
0
0
7
0
% Q
% Arg:
0
14
7
0
0
0
0
0
0
0
7
0
0
74
0
% R
% Ser:
60
7
0
60
0
0
0
67
0
0
0
0
0
0
7
% S
% Thr:
0
7
0
7
7
0
0
7
0
14
7
0
0
7
0
% T
% Val:
7
0
67
0
14
7
7
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
60
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
14
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _